In DOAC treated patients, PCC was applied more often because of gastrointestinal bleeding and patients received higher numbers of ECs as well as tranexamic acid. No significant group differences were found for the following patient outcomes: in-hospital mortality, ICU stay, and length of stay at the ICU or in hospital. Tranexamic acid was used more often in DOAC patients than in VKA patients (28.4% vs. More erythrocyte concentrates (ECs) were given to DOAC patients with blood transfusion ( p = 0.014). Gastrointestinal bleeding was more often found in the DOAC group (18.9% vs. The most frequent bleeding location was intracranial (61.6%, p = 0.881). The most common reason for treatment was acute bleeding in 86.7% of both groups. Out of 199,982 consultations, we studied 346 patients who were given PCC for reversal of either DOAC ( n = 74) or VKA ( n = 272). Our cohort study explores patient characteristics, indications and clinical outcomes for reversal of all DOAC patients receiving PCC at our university emergency department from to, in comparison with patients on VKA. Indications, clinical characteristics and patient outcomes of patients might differ in comparison to reversal of vitamin K antagonists where reversal with PCC is well established. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Prothrombin complex concentrate (PCC) is widely used to reverse the action of direct oral anticoagulants (DOACs) in accordance with current guidelines and because of a lack of specific reversal agents. Portions of this document last updated: Feb. This product is available in the following dosage forms:
This medicine is available only with your doctor's prescription. Vitamin K is routinely given to newborn infants to prevent bleeding problems. Your doctor may treat this by prescribing vitamin K for you. Lack of vitamin K is rare but may lead to problems with blood clotting and increased bleeding.
Your doctor or health care professional may recommend changes in your diet to help these medicines work better. If you are taking anticoagulant medicine (blood thinners), the amount of vitamin K in your diet may affect how well these medicines work. Little vitamin K is lost from foods with ordinary cooking. If you eat a balanced diet containing these foods, you should be getting all the vitamin K you need.
Vitamin K is found in various foods including green leafy vegetables, meat, and dairy products.
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